Kryptopyrrole (Pyrrole Disorder) Urine Test – Assessment of Zinc and Vitamin B6 Deficiency Risk

The Kryptopyrrole Test from Mosaic Diagnostics Laboratory is a urine-based assessment that measures levels of kryptopyrroles, also known as pyrroles or hydroxyhemopyrrolin-2-one (HPL). These compounds are byproducts of abnormal hemoglobin metabolism and can have significant effects on brain chemistry, nutrient balance, and mental health.

When kryptopyrroles accumulate in the body, they bind to and deplete essential nutrients such as vitamin B6 and zinc—two critical cofactors involved in neurotransmitter synthesis and nervous system regulation. The result is often a cascade of symptoms related to mood, focus, and stress resilience.

This simple urine test offers an effective way to detect pyrrole overproduction, helping clinicians uncover one of the hidden biochemical causes of emotional, cognitive, and behavioral imbalances.

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UNDERSTANDING KRYPTOPYRROLES AND THEIR EFFECTS

Kryptopyrroles are considered neurotoxic byproducts that interfere with normal brain and metabolic function when produced in excess. Because they rapidly bind zinc and vitamin B6, elevated pyrrole levels can lead to functional deficiencies, even if dietary intake appears sufficient.

Low zinc and vitamin B6 levels are associated with poor regulation of neurotransmitters such as serotonin, dopamine, and GABA—chemicals responsible for emotional stability, focus, and calm.

Symptoms associated with elevated kryptopyrroles may include:

• Anxiety or panic attacks

• Depression or mood swings

• Poor stress tolerance

• Irritability or explosive anger

• Short attention span or ADHD-type symptoms

• Sleep difficulties

• Sensitivity to light or sound

WHO MAY BENEFIT FROM TESTING

Research and clinical experience suggest a higher incidence of pyrrole disorder (pyroluria) in individuals with:

• Autism Spectrum Disorders (ASD)

• ADHD and learning difficulties

• Anxiety and depression

• Bipolar disorder

• Schizophrenia

• Obsessive-Compulsive Disorder (OCD)

• Alcoholism

• Down Syndrome

Identifying elevated kryptopyrroles allows for targeted nutritional support, often involving zinc, vitamin B6 (pyridoxal-5-phosphate), and antioxidants to help restore biochemical balance and improve mood and cognitive function.

ABOUT THE TEST

The Kryptopyrrole Test requires a urine sample and must be handled carefully due to the light- and temperature-sensitive nature of pyrroles. For this reason, the test is currently available only within the United States to ensure accurate analysis.

INCLUDES

✅ Doctor Authorized Laboratory Test
✅ Free Shipping in the Lower 48 US States
✅ Doctor’s Personalized Written Interpretation of Your Results With Recommendations for Improving Your Health.

Important: This test is not available for residents of New York State. Orders placed from New York will be canceled, and any collected samples will be discarded.