N-Telopeptide (NTx) Urine Test – Evaluation of Bone Turnover and Bone Loss

The Urinary N-Telopeptide (NTx) Test provides a sensitive, non-invasive measure of bone resorption, offering valuable insight into bone health, turnover, and the effectiveness of osteoporosis treatment. This test measures a specific marker of bone breakdown called collagen cross-linked N-telopeptide (NTx)—a byproduct released into the bloodstream and excreted in urine as bone tissue is remodeled.

Elevated NTx levels indicate increased bone loss, which can occur with osteoporosis, osteopenia, menopause, aging, hormonal changes, or certain chronic conditions. Unlike a DEXA scan, which measures bone density, the NTx test assesses dynamic changes in bone metabolism, making it useful for monitoring response to bone-supportive therapies or nutritional interventions over shorter intervals.

Because results can vary with time of day, specimens should be collected using a second-morning void or 24-hour urine sample, following the provided collection instructions carefully.

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Useful For Evaluating:

• Osteoporosis or osteopenia

• Menopause or low estrogen levels

• Amenorrhea in premenopausal women

• Low testosterone in men

• Age-related bone loss

• Corticosteroid or medication-induced bone loss

• Chronic illness or malnutrition

WHY CHOOSE THIS TEST

The Urinary N-Telopeptide (NTx) Test allows for early detection of increased bone breakdown and provides clinicians with a tool to track bone remodeling activity more frequently than an annual DEXA scan. When paired with a urinary calcium test, it gives a more complete picture of bone metabolism and calcium regulation.

INCLUDES

✅ N-Telopeptide (NTx) Urine Test
✅ Doctor’s Review and Interpretation of Results
✅ Personalized Recommendations for Bone Health Support

Test Requirements: A single second-morning urine collection (Test #3003).

Important: This test is not available to residents of New York State. Orders or samples originating from New York will be canceled, and any specimens received will be discarded.